DANA-FARBER CANCER INST
Targeting vulnerabilities of PPM1D-mutant gliomas
Targeting vulnerabilities of PPM1D-mutant gliomas is a funding opportunity from DANA-FARBER CANCER INST, up to 404055, closing January 31, 2028.
Jan 31, 2028
(549d left)Overview
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments. We and others have observed up to 15% of all DMGs to harbor activating mutations in PPM1D which encodes the WIP1 protein phosphatase. Similar mutations are also observed in other cancers,…