DIVISION OF BASIC SCIENCES - NCI
Studies of gene fusions in rhabdomyosarcoma
Studies of gene fusions in rhabdomyosarcoma is a funding opportunity from DIVISION OF BASIC SCIENCES - NCI, up to 762767.
Overview
In our previous studies, we elucidated the mechanisms related to fibroblast growth factor (FGF) signaling in RMS tumors. Within this pathway, the genes for both FGF8 (an FGF ligand) and FGFR4 (an FGF receptor) are downstream transcriptional targets of PAX3::FOXO1 (P3F). We previously used a myoblast model of…