DIVISION OF BASIC SCIENCES - NCI
Studies of amplification in rhabdomyosarcoma
Studies of amplification in rhabdomyosarcoma is a funding opportunity from DIVISION OF BASIC SCIENCES - NCI, up to 673030.
Overview
In our early studies of gene ampli?cation in fusion-positive (FP) rhabdomyosarcoma (RMS), we identi?ed MIR17HG as a key target of the 13q31 amplicon. MIR17HG is a "host gene" in which six microRNAs (miRNAs) (including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a-1) are processed from the RNA transcribed…