EMORY UNIVERSITY
Signal transduction mechanisms used by a group of uncharacterized ITAM- containing receptors in jawless vertebrates
Signal transduction mechanisms used by a group of uncharacterized ITAM- containing receptors in jawless vertebrates is a funding opportunity from EMORY UNIVERSITY, up to 233444, closing June 30, 2028.
Jun 30, 2028
(700d left)Overview
PROJECT SUMMARY Chimeric antigen receptors (CARs) are form of precision immunotherapy approved for the treatment of hematologic malignancies. Nearly all CARs invariantly incorporate the same Immunoreceptor tyrosine-based activation motifs (ITAMs) from human CD3 ZETA to stimulate the primary activation signal pathway…