ALBERT EINSTEIN COLLEGE OF MEDICINE
MTAP-MAT2A synthetic-lethality induced by transition state analogs
MTAP-MAT2A synthetic-lethality induced by transition state analogs is a funding opportunity from ALBERT EINSTEIN COLLEGE OF MEDICINE, up to 692197, closing April 30, 2031.
Apr 30, 2031
(1734d left)Overview
Methylthioadenosine phosphorylase (MTAP) uniquely recycles methylthioadenosine (MTA) in humans, maintaining near zero MTA concentrations. The discovery that MTAP-deleted (MTAP-/-) tumors are uniquely sensitive to co-deletion of MAT2A or PRMT5 has led to intense interest in targeting MAT2A and PRMT5, a new…