DUKE UNIVERSITY
Metabolic regulation of KLHL proteins and targets through O-glycosylation
Metabolic regulation of KLHL proteins and targets through O-glycosylation is a funding opportunity from DUKE UNIVERSITY, up to 422150, closing June 30, 2031.
Jun 30, 2031
(1795d left)Overview
PROJECT SUMMARY/ABSTRACT The 42-member Kelch-like (KLHL) family of human proteins are critical substrate adapters for E3 ubiquitin ligases, and mutations in KLHL genes cause myriad diseases, including neurodegeneration, hypertension, and cancer. However, the upstream regulation and downstream effects of most KLHL…