WASHINGTON STATE UNIVERSITY
Mechanistic Studies of the Role of Genetic Factors in VlsE Antigenic Variation by the Lyme Disease Spirochete
Mechanistic Studies of the Role of Genetic Factors in VlsE Antigenic Variation by the Lyme Disease Spirochete is a funding opportunity from WASHINGTON STATE UNIVERSITY, up to 229500, closing December 31, 2026.
Dec 31, 2026
(153d left)Overview
Project Summary A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variation of the VlsE surface protein. The native vlsE gene has not been receptive to mutation by any available methods over the years, which has greatly impeded progress in…