UNIVERSITY OF ALABAMA AT BIRMINGHAM
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations is a funding opportunity from UNIVERSITY OF ALABAMA AT BIRMINGHAM, up to 404304, closing June 30, 2027.
Jun 30, 2027
(334d left)Overview
Project Summary/Abstract Loss of function progranulin (GRN) mutations, most of which cause haploinsufficiency, are a major genetic cause of frontotemporal dementia (FTD) with TDP-43 pathology (FTD-TDP). Progranulin-boosting therapies are a promising treatment strategy, but the optimal progranulin-boosting strategy…