OHIO STATE UNIVERSITY
Investigating UPF3 paralog function in Nonsense-Mediated mRNA Decay and Genetic Compensation
Investigating UPF3 paralog function in Nonsense-Mediated mRNA Decay and Genetic Compensation is a funding opportunity from OHIO STATE UNIVERSITY, up to 157831, closing March 31, 2027.
Mar 31, 2027
(243d left)Overview
Abstract Nonsense Mediated mRNA Decay (NMD) degrades both aberrant transcripts containing Premature Termination Codons (PTCs) and “normal” transcripts with other specific features. Regulation by NMD is pervasive and estimated to impact around 10% of the transcriptome. UPF3 is a central NMD factor that bridges the…