DANA-FARBER CANCER INST
Flipping the Switch in Cell Cycle Control: Dissecting the Molecular Mechanisms Governing Wee1 Kinase transition from Cdk Inhibitor to Substrate
Flipping the Switch in Cell Cycle Control: Dissecting the Molecular Mechanisms Governing Wee1 Kinase transition from Cdk Inhibitor to Substrate is a funding opportunity from DANA-FARBER CANCER INST, up to 645102, closing June 30, 2031.
Jun 30, 2031
(1795d left)Overview
Abstract Cell cycle checkpoints are essential for maintaining genomic integrity, and their dysregulation is a hallmark of cancer. Among these, the G2-to-M transition is regulated by the kinase WEE1, which delays mitotic entry by phosphorylating and inactivating Cdk1. This modification prevents cell division under…