Evaluating the Cell-Type Specificity and Cellular Targets of Senotherapuetic Compounds with Unknown Mechanisms

Overview

We initially screened eight flavonoids for senolytic activity (i.e., fisetin, myricetin, quercetin, apigenin, epicatechin, cyanidin c1, gingerenone, and procyanidin c1). Of these, fisetin and quercetin showed senescence specific senolytic activity in a dose-response study in both monocytes and renal epithelial cells.…