UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Deoxyuridine Contamination and Innate Immune Signaling
Deoxyuridine Contamination and Innate Immune Signaling is a funding opportunity from UNIVERSITY OF PITTSBURGH AT PITTSBURGH, up to 644234, closing March 31, 2030.
Mar 31, 2030
(1339d left)Overview
ABSTRACT Most chemotherapies target DNA replication, and their efficacy depends on the DNA damage response that integrates DNA repair with the cell cycle. Widely used standard-of-care antimetabolites inhibit thymidylate synthase and increase the incorporation of deoxyuridine (dU) into DNA by polymerases. dU…