UNIVERSITY OF MICHIGAN AT ANN ARBOR
Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia is a funding opportunity from UNIVERSITY OF MICHIGAN AT ANN ARBOR, up to 606736, closing August 31, 2029.
Aug 31, 2029
(1127d left)Overview
Expansion of a hexanucleotide GGGGCC repeat within the first intron of the C9orf72 gene is the primary monogenic cause for both Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Despite its intronic location, expanded GGGGCC repeat is retained in the mature mRNA, supporting a non-canonical…