CREIGHTON UNIVERSITY
Contributions of prion strains and substrains to prion zoonotic potential and evolution
Contributions of prion strains and substrains to prion zoonotic potential and evolution is a funding opportunity from CREIGHTON UNIVERSITY, up to 546705, closing June 30, 2028.
Jun 30, 2028
(700d left)Overview
Prions are infectious protein-only zoonotic agents that can rapidly evolve in a new replication environment. Prion strains are encoded by strain-specific conformations of PrPSc, the infectious form of the host-encoded prion protein, PrPC. Collinge and Clarke hypothesized that prion strains are a mixture of a dominant…