BRIGHAM AND WOMEN'S HOSPITAL
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation is a funding opportunity from BRIGHAM AND WOMEN'S HOSPITAL, up to 347191, closing August 31, 2028.
Aug 31, 2028
(762d left)Overview
The role of T cells in RA is established, but nearly all research has focused on CD4 T cells. We have shown that CD8 T cells are similarly expanded and activated in inflamed RA synovium yet do not belong to the typical granzyme (Gzm) B+ cytotoxic T lymphocyte (CTL) subset. Instead, they express high levels of GzmK…