UNIVERSITY OF NOTRE DAME
Bringing alloreactivity into focus with the lens of TCR cross-reactivity
Bringing alloreactivity into focus with the lens of TCR cross-reactivity is a funding opportunity from UNIVERSITY OF NOTRE DAME, up to 459439, closing June 30, 2027.
Jun 30, 2027
(334d left)Overview
SUMMARY CD8+ T cells drive acute cellular rejection (ACR) of transplanted tissues via alloreactivity. Old paradigms about the broad degeneracy of alloreactivity are giving way to the idea that many, if not most, alloreactive T cells recognize unique peptide-allo-HLA complexes, reflecting what is referred to as…